Vice President-R&D
SSL
Total des années d'expérience :26 years, 6 Mois
Distinction of handling various APIs of Therapeutic categories like Anthelmintics, Anti-malarials, Onco Products, Penems, etc.
Efficiently scaled-up various NCEs such as RBx- 2258, 7796, 7644, 9841 and 8700 using several cost effective routes
Played a key role in development of the following for streamlining operations:
DMF Filing Capability: 10 -12 Nos. in year (with minimum 5 groups in Process R&D)
Total APIs developed for DMF: 35 Nos.
DMF filed: 25 Nos.
Process Patents filed: 35 Nos
Process Patents granted: 6 Nos
Synthetic routes
Process Chemistry
Role:
Involved in evaluation of complete processes that related to patent implication and process safety
Established economically sustainable technologies for scale-up functions
Drafted various technical reports like TDRs, Scale-up Guides, Dossiers, etc. for US & EU filings purpose
Accountable for development of IP knowledge and protection of IP wealth for various FTF products efficiently
Resolved various cGMP/regulatory issues in process chemistry for effective snapshots
Handled complete SHE functions for the Process Chemistry and Kilo labs
Role:
Looked after the development of non-infringing & optimization of processes of various APIs viz. Tazobactam, Meropenem, Biotin, Sertraline, Terbinafine, Paroxetine, Modafinil, Trandolapril, Felodipine, Lansoprazole, Memantine, Duloxetine, Gemifloxacin, Pantoprazole, Paliperidone, Pramipexole, Eszopiclone, Losartan, Alendronate, Residronate, Levofloxacin, Valsartan, Telmisartan, Desmethyl venlafaxine, Clopidogrel, etc. within cost economic, less waste and easily scalable
Assessed several technology development reports and prepared the DMF filing functions
Instrumental in validation of various processes as well as transferred the bench scale processes into commercial scales as per the cGMP guidelines
Involved in designing of laboratory expts. as per the Taguchi methods
Supervised a team of 45 Chemists, Scientists and Chem Engrs. /Technologists in an effective way
technical know-how transfer and demonstration of process of Cephalosporin -C and 7-ACA
Overseeing various functions entailing tech transfer, process development, management of process chemistry team analytical research development, IP & Pilot plant operation groups, etc. for streamlining operations
Heading a team of aprrox. 85 Scientists
Looking after complete process of CRAMs for better snapshots
Accountable for taking various business development related decisions for company’s growth & excellence
Synthesis and Study of Organic Compounds of Possible Therapeutic Values
Journal Publications: Synthesis, characterization and molecular docking studies of some new 1,3,4-oxadiazolines bearing 6-methylpyridine moiety for antimicrobial property. P C Shyma, Balakrishna Kalluraya, S K Peethambar, Sandeep Telkar, T Arulmoli; European journal of medicinal chemistry 08/2013; 68C:394-404 Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. N Chidananda, Boja Poojary, V Sumangala, N Suchetha Kumari, Prashanth Shetty, T Arulmoli; European journal of medicinal chemistry 02/2012; 51:124-36 (2E)-1-[2, 3-Dichloro-6-methyl-5-(trifluoro-meth-yl)phen-yl]-2-(1-phenyl-ethyl-idene)hydrazine. Hoong-Kun Fun, Wan-Sin; Loh, Manjunath Bhat, T Arulmoli, G K Nagaraja; Acta Crystallographica Section E Structure Reports Online 11/2012; 68(Pt 11):o3189 1-[2-(4-Chloro-phen-yl)-5-phenyl-2,3-dihydro-1,3,4-oxadiazol-3-yl]ethanone; Hoong-Kun Fun, Suhana Arshad, P C Shyma, Balakrishna Kalluraya, T Arulmoli; Acta Crystallographica Section E Structure Reports Online 06/2012; 68(Pt 6):o190 Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines.V Sumangala, Boja Poojary, N Chidananda, T Arulmoli, Shalini Shenoy; European journal of medicinal chemistry 04/2012; 54:59-64 Synthesis of some new pyrazolone derivatives as potent antimicrobial agents, A. M. Vijesh, Arun M. Isloor, Shrikrishna Isloor, K. N. Shivananda, P. C. Shyma, T. Arulmoli; Der Pharma Chemica. 01/2011; 3:454-463 Molecular docking studies of some new imidazole derivatives for antimicrobial properties., A.M. Vijesh, Arun M. Isloor, Sandeep Telkar, T. Arulmoli; Arabian Journal of Chemistry 01/2011 Diethyl-4-[5-(biphenyl-4-yl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate-ethanol monosolvate. Hoong-Kun Fun, Madhukar Hemamalini, A M Vijesh, Arun M Isloor, T Arulmoli Acta Crystallographica Section E Structure Reports Online 07/2011; 67(Pt 7):o1768-9 Hantzsch reaction: synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents.A M Vijesh, Arun M Isloor, S K Peethambar, K N Shivananda, T Arulmoli, Nishitha A Isloor; European journal of medicinal chemistry 09/2011; 46(
Specialized in Pharmaceutical Chemistry
courses: Patent Publications: WO 2012/081033: Process for Preparation of Imipenem; Andrew Gnanaprakasam, Ganapathy Veeramani, Michael Sekar Jeyaraj, Arulmoli Thangavel: Sequent Scientific Ltd. in Jun’12 WO 2012/081035: Process for Preparation of