Head R &D
Parmax Pharma Ltd
Total years of experience :29 years, 1 Months
Twenty three years of accomplished industrial experience in Research and Process Development, Manufacturing support and Documentation.
Cost reduction and development and Application of newer synthetic reagents and innovative commercially viable technologies for pharmaceutical development.
•Products developed for cost reduction - Galantamine, Clarithromycin, Carbamazepine. Levofloxacin Hemihydrate, Sertraline HCL Form II.
•API’s developed - Valgancilcovir, Ganciclovir, Panipenem, Rosuvastatin Atorvastatain, Coenzyme Q10, Biotin and Lisinopril.
•Application of design of experiments (DOE) and QBD (Quality by design) in identification of critical parameters for process optimization and cost reduction.
•Competence to design and conduct multistep complex organic synthesis using newer reagents and development of new practical and economical reaction pathways to API
•Developed commercially viable process for the isolation of Coenzyme Q10 and its synthesis from solanesol
•Impurity profiling of drug substances: Isolation, characterization and synthesis of drug related substances (impurities), degradation products of active pharma ingredients.
•Skills: Computer skills; Sound knowledge of application of popular packages of chemical structure drawing (Chemsketch, ISIS, ACD labs, Chemdraw). Well versed with most of databases and internet searches.
•Coaches and trains R&D staff, prepares on job training programs. Evaluate performance of staff, recommends promotion, additional training etc.
•Coordination with Quality Control to ensure quality compliance and timely completion of the projects.
•GLP coordinator for the implementation of the GLP
Significant and Outstanding Career Accomplishments:
•Developed and scaled up a cost effective process for the commercial
Production of Atorvastatin Calcium Crystalline for US and less regulated
markets.
•Developed and scaled up a cost effective and non infringing process
for the commercial production of Galantamine HBr for US.
•Developed a patent free process for preparing Carbamazepine from
Iminostilbene vide patent No.US6245908 dated 2001-06-12.
•Introduced modifications in manufacturing process of Carbamazepine and its intermediates. With these modifications production capacity increased from 4.0 MT to 7.0 MT per month with the existing facility and production cost reduced from Rs. 2000/- per kg to Rs. 900/- per kg
Responsible for route selection for the development of non infringing process and the filing strategies of the final active pharma ingredients and intermediates.
•Responsible for technology transfer from R&D to Plant and Pilot Plant while implementing strategies, managing critical issues of multiple projects and teams.
•Addressing chemistry related problems and other trouble shootings in production of final Active Pharma Ingredients and intermediates.
•Implementation of innovative synthetic technologies to reduce cost and improve efficiency in commercialization to achieve company’s global goals.
•Supervision of a team of 6 chemists and 4 scientists for R&D and manufacturing support
Responsible for route selection for the development of non infringing process and the filing strategies of the final active pharma ingredients.
•Responsible for technology transfer from R&D to Plant and Pilot Plant while implementing strategies, managing critical issues of multiple projects and teams.
•Addressing chemistry related problems and other trouble shootings in production of final Active Pharma Ingredients.
•Implementation of innovative synthetic technologies to reduce cost and improve efficiency in commercialization to achieve company’s global goals.
•Supervision of a team of 4 chemists and 2 scientists for R&D and manufacturing support
Responsible for technology transfer from R&D to Plant and Pilot Plant while implementing strategies, managing critical issues of multiple projects and teams.
•Addressing chemistry related problems and other trouble shootings in production of final Active Pharma Ingredients.
•Implementation of innovative synthetic technologies to reduce cost and improve efficiency in commercialization to achieve company’s global goals.
•Supervision of a team of 3 chemists and 1 scientist for R&D and manufacturing support
Responsible for Process development at R&D and technology transfer to Plant managing critical issues of the Projects.
•Addressing chemistry related problems and other trouble shootings in production of final Active Pharma Ingredients.
•Supervision of a team of 2 chemists for R&D and manufacturing support
Currently Jubilant Organosys), Gajraula, U.P.
•Responsible for Process development at R&D and technology transfer to Plant managing critical issues of the Projects.
•Addressing chemistry related problems and other trouble shootings in production of final Active Pharma Ingredients
Responsible for Process development at R&D and technology transfer to Plant managing critical issues of the Projects.
•Addressing chemistry related problems and other trouble shootings in production of final Active Pharma Ingredients
Responsible for Process development at R&D and technology transfer to Plant managing critical issues of the Projects.
Patents:
•Developed a commercial and non infringing process for the
preparation of Co Enzyme Q10 vides Paten No. WO2007/004090A2
•Developed a patent free process for preparing Carbamazepine from
Iminostilbene vide patent No.US6245908 dated 2001-06-12.
•Developed a patent free process, for manufacturing Biotin vide
International Publication Number WO 2004/041830 A2 dated 21 MAY 2004.
•Developed a Patent free process for crystalline forms of Atorvastatin Magnesium vide Patent Number 20090306173.
Conferences/Symposia/Workshop
Participated in number of different National conferences, symposia and workshops.
Ist class second in University in order of merit
Ist class third in University in order of merit